in-vitro preclinical research

TR-MOD

TR-MOD multifunctional antimicrobial peptide

Antimicrobial Peptides

TR-MOD inhibited Pseudomonas in broth, interfered with biofilm formation, and increased fibroblast migration in vitro. It did not heal wounds, eradicate mature biofilms, or establish human safety.

Research status: in-vitro preclinical research

Deep Dives on TR-MOD

Start here for the plain-English articles connected to this peptide.

Research Guides13 min read

TR-MOD: What a Biofilm-and-Fibroblast Lab Study Can—and Cannot—Show About a “Wound-Healing” Peptide

TR-MOD inhibited Pseudomonas in broth, interfered with biofilm formation, and increased fibroblast migration in vitro. It did not heal wounds, eradicate mature biofilms, or establish human safety.

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Quick Facts

Origin: De novo optimized 16-amino-acid peptide derived from a spider venom-gland transcriptomic lead
Category: Antimicrobial Peptides

Mechanisms

MICs were measured in three independent experiments across one reference and three multidrug-resistant Pseudomonas aeruginosa strains
biofilm crystal-violet assays used three biological replicates with six technical replicates per condition
fibroblast migration, cytocompatibility, hemolysis, protein and inhibitor experiments were reported with assay-specific controls and triplicate biological replication
membrane depolarization and permeability signals

Research Areas