Preclinical

NF27

NF27 oncolytic peptide

Oncolytic Peptides

NF27 eliminated measurable tumors in some mice after direct intratumoral exposure, but the short, model-specific preclinical evidence does not establish human efficacy or systemic safety.

Research status: Preclinical research only — no human clinical trials published

Deep Dives on NF27

Start here for the plain-English articles connected to this peptide.

evidence-literacy15 min read

NF27 Eradicated Some Mouse Tumors—Why That Is Not Yet a Cancer Treatment

NF27 eliminated measurable tumors in some mice after direct intratumoral exposure, but the short, model-specific preclinical evidence does not establish human efficacy or systemic safety.

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Quick Facts

Origin: CKS1-derived experimental oncolytic peptide reported by Furukawa and colleagues
Category: Oncolytic Peptides

Mechanisms

CKS1-derived structure-activity comparisons with inactive near-neighbor peptides
Two-hour LDH and corroborative alamarBlue assays across murine and human cell lines
NCI-60 five-concentration screen across 59 evaluable lines
Direct NF27 versus LTX-315 cell-assay and hemolysis comparisons in the final supplement

Research Areas